Multiple Sclerosis - How to Apply the McDonald Criteria

This activity has been designed to address the educational needs of clinicians in multiple sclerosis (MS) centers or community neurology practices involved in the diagnosis of patients with multiple MS, including specialist physicians, primary care clinicians who manage and/or treat a high volume of neurological conditions, physician assistants (PAs), nurse practitioners (NPs), and nurses.

Supported by an educational grant from:


Activity Information


Original release date: December 18, 2019
Expiration date: December 18, 2020
Estimated time to complete each activity: 0.5 hours



The Science and Strategies Behind Successful MS Diagnosis


Are You Confident in Your Readiness to Diagnose MS?





Ilya Kister, MD
Associate Professor, Department of Neurology
NYU Langone Health
NYU Langone Multiple Sclerosis Comprehensive Care Center
New York, NY


Stephen Krieger, MD
Associate Professor of Neurology
Corinne Goldsmith Dickenson Center for MS
Icahn School of Medicine at Mount Sinai
New York, NY


Andrew J. Solomon, MD
Associate Professor, Department of Neurological Sciences
Division Chief, Multiple Sclerosis
The University of Vermont
Burlington, VT

Program Overview

The accuracy and speed required to diagnose multiple sclerosis depends on the expertise of the clinician. Accurate interpretation of MRI findings is essential. A missed diagnosis – or misdiagnosis – leads to delays in offering appropriate therapy. In the first of 2 activities, experts discuss and interpret updates to the McDonald MS diagnostic criteria. The second offers case studies that challenge learners to evaluate the radiological and clinical evidence that supports – or does not support – their diagnosis.

Learning Objectives

At the conclusion of this activity, participants should be better able to:

  • Describe the clinical features, imaging findings, and laboratory results that support and that do not support a diagnosis of multiple sclerosis (MS)
  • Detail the key components of the 2017 revisions to the McDonald criteria, and when and how those criteria should be employed in assessing patients for MS
  • Outline and evaluation strategy for correctly diagnosing MS

Joint Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group (Global) and Global Academy for Medical Education. Global is accredited by the ACCME to provide continuing medical education for physicians.

Physician Credit Designation

Global Education Group designates these enduring activities for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in
the activity.

Nurse Credit Designation
Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.
This educational activity for 0.5 contact hour is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

To Claim CME/CE Credit

There are no fees for participating and receiving CME/CE credit for this activity. During the period December 18, 2019 through December 18, 2020, participants must read the learning objectives and faculty disclosures and study the educational activity. Upon completing either or both of the online activities in this curriculum, participants will automatically receive their CME/CAE certificate(s).

Disclosures of Conflicts of Interest

Global Education Group (Global) requires instructors, planners, managers and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

Faculty Disclosures:

Ilya Kister, MD: Consultant/Independent Contractor: F. Hoffmann-La Roche, Genentech, Arcus Medica, GrandRounds Grant/Research Support: F. Hoffmann-La Roche, Genentech, Biogen Idec

Stephen Krieger, MD: Consultant/Independent Contractor: Biogen, EMD Serono, Genentech, Genzyme, Mallinckrodt, MedDay, Novartis, Teva, TG Therapeutics Honoraria: Biogen, EMD Serono, Novartis

Andrew J. Solomon, MD: Consultant/Independent Contractor: Biogen, EMD Serono Grant/Research Support: Biogen Advisory Board: EMD Serono

Planners/Managers: The following Global Education Group planners and managers have nothing to disclose: Lindsay Borvansky, Ashley Marostica, Andrea Funk, Liddy Knight, Ashley Cann

The following Global Academy for Medical Education planners and managers have nothing to disclose: Tom Garry, Ron Schaumburg, Nicola Sirdevan

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and Global Academy for Medical Education do not recommend the use of any agent outside of the labeled indications.


The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Internet activity

Computer System Requirements

Supported Browsers:
Internet Explorer 9.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux

Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above.